Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients

Alhassan Mohamed Hassan; Amir Fawzy Abdelhamid; Hosam Barakat Barakat; Soliman Mohamed Soliman; Hossamaldin Mohamed Soliman; Mohamed Abdalla Hablus; Mahmoud Mostafa Alshareef

doi:doi:10.11648/j.js.20200804.15

Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients

Alhassan Mohamed Hassan, Amir Fawzy Abdelhamid, Hosam Barakat Barakat, Soliman Mohamed Soliman, Hossamaldin Mohamed Soliman, Mohamed Abdalla Hablus, Mahmoud Mostafa Alshareef

Published in Journal of Surgery (Volume 8, Issue 4)

Received: 27 May 2020 Accepted: 28 June 2020 Published: 7 July 2020

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Abstract

Aim: This study is to assess tumor size as a prognostic factor predicting outcomes after one staged hepatectomy for cirrhotic patients with solitary hepatocellular carcinoma. Patients and methods: The study included 41 patients with single hepatocellular carcinoma (HCC) of different sizes who underwent single-stage hepatectomy. Patients were divided according to their tumor size into 2 groups, group A involved patient with tumors ≤ 5 cm and group B which involved patients with tumors > 5 cm. The effect of the tumor size on overall survival and disease-free survival was studied in both groups. Results: The mean age of the studied groups was 59.60±6.89 years. Hepatitis C infection was found 82.9% of patients. Six patients (17.1%) received treatment of HCV. All patients were of Child-Pugh class A (77.1% were scores 5 and 22.9% were score 6). The median Alpha-fetoprotein (AFP) level was 240 ng/ml. The mean operative time was 186.4±52.4 min. During the follow-up period (12-24 months), 12 patients (34.3%) developed recurrence. The mean time of recurrence was 15.50±4.23 months. Cumulative disease-free survival (DFS) at the end of the study was 65.7%. The cumulative overall survival (OAS) proportion at the end of the study was 74.3%. Conclusion: Our results suggest that surgical resection for large HCC is safe and effective and that the first-line treatment for large HCC to be considered is surgical resection in selected patients. Our study showed that hepatectomy for large HCC could be performed with an acceptable morbidity and mortality rate. With the improvement in patient selection and treatment strategy, solitary large HCC is not a contraindication to surgical therapy.

Published in	Journal of Surgery (Volume 8, Issue 4)
DOI	10.11648/j.js.20200804.15
Page(s)	123-131
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Tumor Size, Solitary HCC, Resection, Single Stage

References

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Alhassan Mohamed Hassan, Amir Fawzy Abdelhamid, Hosam Barakat Barakat, Soliman Mohamed Soliman, Hossamaldin Mohamed Soliman, et al. (2020). Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients. Journal of Surgery, 8(4), 123-131. https://doi.org/10.11648/j.js.20200804.15

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ACS Style

Alhassan Mohamed Hassan; Amir Fawzy Abdelhamid; Hosam Barakat Barakat; Soliman Mohamed Soliman; Hossamaldin Mohamed Soliman, et al. Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients. J. Surg. 2020, 8(4), 123-131. doi: 10.11648/j.js.20200804.15

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AMA Style

Alhassan Mohamed Hassan, Amir Fawzy Abdelhamid, Hosam Barakat Barakat, Soliman Mohamed Soliman, Hossamaldin Mohamed Soliman, et al. Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients. J Surg. 2020;8(4):123-131. doi: 10.11648/j.js.20200804.15

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@article{10.11648/j.js.20200804.15,
  author = {Alhassan Mohamed Hassan and Amir Fawzy Abdelhamid and Hosam Barakat Barakat and Soliman Mohamed Soliman and Hossamaldin Mohamed Soliman and Mohamed Abdalla Hablus and Mahmoud Mostafa Alshareef},
  title = {Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients},
  journal = {Journal of Surgery},
  volume = {8},
  number = {4},
  pages = {123-131},
  doi = {10.11648/j.js.20200804.15},
  url = {https://doi.org/10.11648/j.js.20200804.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20200804.15},
  abstract = {Aim: This study is to assess tumor size as a prognostic factor predicting outcomes after one staged hepatectomy for cirrhotic patients with solitary hepatocellular carcinoma. Patients and methods: The study included 41 patients with single hepatocellular carcinoma (HCC) of different sizes who underwent single-stage hepatectomy. Patients were divided according to their tumor size into 2 groups, group A involved patient with tumors ≤ 5 cm and group B which involved patients with tumors > 5 cm. The effect of the tumor size on overall survival and disease-free survival was studied in both groups. Results: The mean age of the studied groups was 59.60±6.89 years. Hepatitis C infection was found 82.9% of patients. Six patients (17.1%) received treatment of HCV. All patients were of Child-Pugh class A (77.1% were scores 5 and 22.9% were score 6). The median Alpha-fetoprotein (AFP) level was 240 ng/ml. The mean operative time was 186.4±52.4 min. During the follow-up period (12-24 months), 12 patients (34.3%) developed recurrence. The mean time of recurrence was 15.50±4.23 months. Cumulative disease-free survival (DFS) at the end of the study was 65.7%. The cumulative overall survival (OAS) proportion at the end of the study was 74.3%. Conclusion: Our results suggest that surgical resection for large HCC is safe and effective and that the first-line treatment for large HCC to be considered is surgical resection in selected patients. Our study showed that hepatectomy for large HCC could be performed with an acceptable morbidity and mortality rate. With the improvement in patient selection and treatment strategy, solitary large HCC is not a contraindication to surgical therapy.},
 year = {2020}
}

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TY  - JOUR
T1  - Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients
AU  - Alhassan Mohamed Hassan
AU  - Amir Fawzy Abdelhamid
AU  - Hosam Barakat Barakat
AU  - Soliman Mohamed Soliman
AU  - Hossamaldin Mohamed Soliman
AU  - Mohamed Abdalla Hablus
AU  - Mahmoud Mostafa Alshareef
Y1  - 2020/07/07
PY  - 2020
N1  - https://doi.org/10.11648/j.js.20200804.15
DO  - 10.11648/j.js.20200804.15
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 123
EP  - 131
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20200804.15
AB  - Aim: This study is to assess tumor size as a prognostic factor predicting outcomes after one staged hepatectomy for cirrhotic patients with solitary hepatocellular carcinoma. Patients and methods: The study included 41 patients with single hepatocellular carcinoma (HCC) of different sizes who underwent single-stage hepatectomy. Patients were divided according to their tumor size into 2 groups, group A involved patient with tumors ≤ 5 cm and group B which involved patients with tumors > 5 cm. The effect of the tumor size on overall survival and disease-free survival was studied in both groups. Results: The mean age of the studied groups was 59.60±6.89 years. Hepatitis C infection was found 82.9% of patients. Six patients (17.1%) received treatment of HCV. All patients were of Child-Pugh class A (77.1% were scores 5 and 22.9% were score 6). The median Alpha-fetoprotein (AFP) level was 240 ng/ml. The mean operative time was 186.4±52.4 min. During the follow-up period (12-24 months), 12 patients (34.3%) developed recurrence. The mean time of recurrence was 15.50±4.23 months. Cumulative disease-free survival (DFS) at the end of the study was 65.7%. The cumulative overall survival (OAS) proportion at the end of the study was 74.3%. Conclusion: Our results suggest that surgical resection for large HCC is safe and effective and that the first-line treatment for large HCC to be considered is surgical resection in selected patients. Our study showed that hepatectomy for large HCC could be performed with an acceptable morbidity and mortality rate. With the improvement in patient selection and treatment strategy, solitary large HCC is not a contraindication to surgical therapy.
VL  - 8
IS  - 4
ER  -

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Author Information

Alhassan Mohamed Hassan

Department of Surgery, Faculty of Medicine, Tanat University, Tanta, Egypt
Amir Fawzy Abdelhamid

Department of Surgery, Faculty of Medicine, Tanat University, Tanta, Egypt
Hosam Barakat Barakat

Department of Surgery, Faculty of Medicine, Tanat University, Tanta, Egypt
Soliman Mohamed Soliman

Department of Surgery, Faculty of Medicine, Tanat University, Tanta, Egypt
Hossamaldin Mohamed Soliman

Departement of Surgery, Menofeya National Liver Insistute, Menofeya University, Shebin El-kom, Egypt
Mohamed Abdalla Hablus

Department of Surgery, Faculty of Medicine, Tanat University, Tanta, Egypt
Mahmoud Mostafa Alshareef

Department of Surgery, Faculty of Medicine, Tanat University, Tanta, Egypt

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APA Style

Alhassan Mohamed Hassan, Amir Fawzy Abdelhamid, Hosam Barakat Barakat, Soliman Mohamed Soliman, Hossamaldin Mohamed Soliman, et al. (2020). Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients. Journal of Surgery, 8(4), 123-131. https://doi.org/10.11648/j.js.20200804.15

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ACS Style

Alhassan Mohamed Hassan; Amir Fawzy Abdelhamid; Hosam Barakat Barakat; Soliman Mohamed Soliman; Hossamaldin Mohamed Soliman, et al. Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients. J. Surg. 2020, 8(4), 123-131. doi: 10.11648/j.js.20200804.15

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AMA Style

Alhassan Mohamed Hassan, Amir Fawzy Abdelhamid, Hosam Barakat Barakat, Soliman Mohamed Soliman, Hossamaldin Mohamed Soliman, et al. Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients. J Surg. 2020;8(4):123-131. doi: 10.11648/j.js.20200804.15

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@article{10.11648/j.js.20200804.15,
  author = {Alhassan Mohamed Hassan and Amir Fawzy Abdelhamid and Hosam Barakat Barakat and Soliman Mohamed Soliman and Hossamaldin Mohamed Soliman and Mohamed Abdalla Hablus and Mahmoud Mostafa Alshareef},
  title = {Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients},
  journal = {Journal of Surgery},
  volume = {8},
  number = {4},
  pages = {123-131},
  doi = {10.11648/j.js.20200804.15},
  url = {https://doi.org/10.11648/j.js.20200804.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20200804.15},
  abstract = {Aim: This study is to assess tumor size as a prognostic factor predicting outcomes after one staged hepatectomy for cirrhotic patients with solitary hepatocellular carcinoma. Patients and methods: The study included 41 patients with single hepatocellular carcinoma (HCC) of different sizes who underwent single-stage hepatectomy. Patients were divided according to their tumor size into 2 groups, group A involved patient with tumors ≤ 5 cm and group B which involved patients with tumors > 5 cm. The effect of the tumor size on overall survival and disease-free survival was studied in both groups. Results: The mean age of the studied groups was 59.60±6.89 years. Hepatitis C infection was found 82.9% of patients. Six patients (17.1%) received treatment of HCV. All patients were of Child-Pugh class A (77.1% were scores 5 and 22.9% were score 6). The median Alpha-fetoprotein (AFP) level was 240 ng/ml. The mean operative time was 186.4±52.4 min. During the follow-up period (12-24 months), 12 patients (34.3%) developed recurrence. The mean time of recurrence was 15.50±4.23 months. Cumulative disease-free survival (DFS) at the end of the study was 65.7%. The cumulative overall survival (OAS) proportion at the end of the study was 74.3%. Conclusion: Our results suggest that surgical resection for large HCC is safe and effective and that the first-line treatment for large HCC to be considered is surgical resection in selected patients. Our study showed that hepatectomy for large HCC could be performed with an acceptable morbidity and mortality rate. With the improvement in patient selection and treatment strategy, solitary large HCC is not a contraindication to surgical therapy.},
 year = {2020}
}

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TY  - JOUR
T1  - Impact of Tumor Size as a Prognostic Factor After One Stage Liver Resection for Solitary Hepatocellular Carcinoma in Cirrhotic Patients
AU  - Alhassan Mohamed Hassan
AU  - Amir Fawzy Abdelhamid
AU  - Hosam Barakat Barakat
AU  - Soliman Mohamed Soliman
AU  - Hossamaldin Mohamed Soliman
AU  - Mohamed Abdalla Hablus
AU  - Mahmoud Mostafa Alshareef
Y1  - 2020/07/07
PY  - 2020
N1  - https://doi.org/10.11648/j.js.20200804.15
DO  - 10.11648/j.js.20200804.15
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 123
EP  - 131
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20200804.15
AB  - Aim: This study is to assess tumor size as a prognostic factor predicting outcomes after one staged hepatectomy for cirrhotic patients with solitary hepatocellular carcinoma. Patients and methods: The study included 41 patients with single hepatocellular carcinoma (HCC) of different sizes who underwent single-stage hepatectomy. Patients were divided according to their tumor size into 2 groups, group A involved patient with tumors ≤ 5 cm and group B which involved patients with tumors > 5 cm. The effect of the tumor size on overall survival and disease-free survival was studied in both groups. Results: The mean age of the studied groups was 59.60±6.89 years. Hepatitis C infection was found 82.9% of patients. Six patients (17.1%) received treatment of HCV. All patients were of Child-Pugh class A (77.1% were scores 5 and 22.9% were score 6). The median Alpha-fetoprotein (AFP) level was 240 ng/ml. The mean operative time was 186.4±52.4 min. During the follow-up period (12-24 months), 12 patients (34.3%) developed recurrence. The mean time of recurrence was 15.50±4.23 months. Cumulative disease-free survival (DFS) at the end of the study was 65.7%. The cumulative overall survival (OAS) proportion at the end of the study was 74.3%. Conclusion: Our results suggest that surgical resection for large HCC is safe and effective and that the first-line treatment for large HCC to be considered is surgical resection in selected patients. Our study showed that hepatectomy for large HCC could be performed with an acceptable morbidity and mortality rate. With the improvement in patient selection and treatment strategy, solitary large HCC is not a contraindication to surgical therapy.
VL  - 8
IS  - 4
ER  -

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