Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report

Michael Masoomi; Alshaima Al-Shammeri; Esraa Al-Qattan; Haytham Ramzy; Hany A Elrahman; Aisha Al-Qattan; Latifah Al-Kandari; Iman Al-Shammeri

doi:doi:10.11648/j.ajim.20200805.15

Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report

Michael Masoomi, Alshaima Al-Shammeri, Esraa Al-Qattan, Haytham Ramzy, Hany A Elrahman, Aisha Al-Qattan, Latifah Al-Kandari, Iman Al-Shammeri

Published in American Journal of Internal Medicine (Volume 8, Issue 5)

Received: 24 July 2020 Accepted: 10 August 2020 Published: 25 August 2020

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Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the infectious disease COVID-19, was declared a global pandemic in March 2020. The SARS-CoV-2 infection has polymorphic clinical presentations. The real time PCR is the reference diagnostic test; however, it can only detect the presence of virus for a specific window of time and its sensitivity has been reported as low as 60–70%. Case: We report a clinical case for a 28-year-old male patient. His clinical history included known NHL (large B-cell lymphoma) that treated with chemotherapy and autologous bone marrow transplant in 2017. He initially presented with fewer, URTI (upper respiratory infection) and weight loss to have a PET/CT scan for restaging. The follow up PET/CT scan, suggested no worrisome FDG metabolic activity elsewhere to suggest disease recurrence, though, hypermetabolic mediastinal lymph nodes, which were kept with active infectious process and bilateral FDG-avid ground glass attenuation in between the consolidation patches were noted. The follow up RT-PCR post PET/CT scan was proved to be positive. A developed pixelated quantitative map of CT part of the lung using MATLAB showed clearly severity of the lung disease that strongly suggested COVID-19 lung in association with the positive RT-PCR. FDG PET/CT has the potential to add value to the challenges of diagnosing complications caused by viruses such as COVID-19.

Published in	American Journal of Internal Medicine (Volume 8, Issue 5)
DOI	10.11648/j.ajim.20200805.15
Page(s)	221-225
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

PET/CT, MATLAB, COVID-19, Oncology Patient

References

[1]	Naming the coronavirus disease (COVID-19) and the virus that causes it. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technicalguidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it (Accessed 03/22/2020).
[2]	Gorbalenya AE, Baker SC, Baric RS, et al. Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study Group. https://doi.org/10.1101/2020.02.07.937862 doi: bioRxiv preprint.
[3]	WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarksat-the-media-briefing-on-covid-19,11-March-2020 (Accessed on 03/22/2020).
[4]	Chung M, Bernheim A, Mei X, Zhang N, Huang M, Zeng X, etal. CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology. 2020 Apr; 295 (1): 202-207. Doi: 10.1148/radiol.2020200230. Epub 2020 Feb 4. PubMed PMID: 32017661.
[5]	Kong W and Agarwal P. Chest Imaging Appearance of COVID-19 Infection. Radiology Cardiothoracic Imaging 2020 February 13 (published online), doi: 10.1148/ryct.2020200028.
[6]	Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N, etal. Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection. Radiology. 2020 Feb 20: 200463. doi: 10.1148/radiol.2020200463. [Epub ahead of print] PubMed PMID: 32077789.
[7]	Pan F, Ye T, Sun P, Gui S, Liang B, Li L, etal. Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia. Radiology. 2020 Feb 13: 200370. doi: 10.1148/radiol.2020200370. [Epub ahead of print] PubMed PMID: 32053470.
[8]	Bai HX, Hsieh B, Xiong Z, Halsey K, Choi JW, Tran TML, Pan I, Shi LB, Wang DC, etal. Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT. Radiology. 2020 Mar 10: 200823. doi: 10.1148/radiol.2020200823. [Epub ahead of print] PubMed PMID: 32155105.
[9]	Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. AJR Am J Roentgenol. 2020 Mar 14: 1-7. doi: 10.2214/AJR.20.23034. [Epub ahead of print] PubMed PMID: 32174129.
[10]	Kanne JP, Little BP, Chung JH, Elicker BM, Ketai LH. Essentials for radiologists on COVID-19: an update radiology scientific expert panel. Radiology. 2020295 (1); 16–17.
[11]	Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020. https://doi.org/10.1016/S1473-3099(20)30086-4.
[12]	Lee EYP, NgMY, Khong PL. COVID-19 pneumonia: what has CT taught us. Lancet Infect Dis. 2020. https://doi.org/10.1016/S1473-3099(20)30134-1.
[13]	Qin C, Liu F, Yen TC, Lan X. 18F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases. Eur J Nucl Med Mol Imaging. 2020. https://doi.org/10.1007/s00259-020-04734-w.
[14]	Capitanio S, Nordin AJ, Noraini AR, Rossetti C. PET/CT in non-oncological lung diseases: current applications and future perspectives. Eur Respir Rev. 2016; 25: 247–58.
[15]	Jones HA, Marino PS, Shakur BH, Morrell NW. In vivo assessment of lung inflammatory cell activity in patients with COPD and asthma. Eur Respir J. 2003; 21: 567–73.
[16]	Albano D, Bertagna F, Bertoli M, Bosio G, Lucchini S, Motta F, et al. Incidental findings suggestive of COVID-19 in asymptomatic patients undergoing nuclear medicine procedures in a high-prevalence region. J Nucl Med 2020; 61: 632–6pp. doi: https://doi.org/10.2967/jnumed.120.246256.
[17]	Long C, Xu H, Shen Q, Zhang X, Fan B, Wang C, Zeng B, Li Z, Li X, Li H, Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? European Journal of Radiology (2020), doi: https://doi.org/10.1016/j.ejrad.2020.108961.
[18]	Boom Ting Kung A. An Update on the Role of 18F-FDG-PET/CT in Major Infectious and Inflammatory Diseases. [online] PubMed Central 2020; Accessed 8 May 2020.
[19]	Deng Y, Lei L, Chen Y, Zhang W. The potential added value of FDG PET/CT for COVID-19 pneumonia. Eur J Nucl Med Mol Imaging 2020; 47: 1634–5. doi: https://doi.org/10.1007/s00259-020-04767-115.
[20]	McDermott S, Kilcoyne A, Wang Y, Scott JA, Halpern EF, Ackman JB. Comparison of the 18F-FDG avidity at PET of benign and malignant pure ground-glass opacities: a paradox? Clin Radiol 2019; 74: 187–95. doi: https://doi.org/10.1016/j.Card. 2018. 12. 009.
[21]	Qin C, Liu F, Yen T-C, Lan X. 18F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases. Eur J Nucl Med Mol Imaging 2020; 47: 1281–6pp. doi: https://doi.org/10.1007/s00259- 020- 04734-w.
[22]	Setti L, Kirienko M, Dalto SC, Bonacina M, Bombardieri E. Fdg-PET/CT findings highly suspicious for COVID-19 in an Italian case series of asymptomatic patients. Eur J Nucl Med Mol Imaging 2020; 47: 1649–56. doi: https://doi.org/10.1007/s00259-020-04819-6.

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APA Style

Michael Masoomi, Alshaima Al-Shammeri, Esraa Al-Qattan, Haytham Ramzy, Hany A Elrahman, et al. (2020). Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report. American Journal of Internal Medicine, 8(5), 221-225. https://doi.org/10.11648/j.ajim.20200805.15

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ACS Style

Michael Masoomi; Alshaima Al-Shammeri; Esraa Al-Qattan; Haytham Ramzy; Hany A Elrahman, et al. Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report. Am. J. Intern. Med. 2020, 8(5), 221-225. doi: 10.11648/j.ajim.20200805.15

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AMA Style

Michael Masoomi, Alshaima Al-Shammeri, Esraa Al-Qattan, Haytham Ramzy, Hany A Elrahman, et al. Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report. Am J Intern Med. 2020;8(5):221-225. doi: 10.11648/j.ajim.20200805.15

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@article{10.11648/j.ajim.20200805.15,
  author = {Michael Masoomi and Alshaima Al-Shammeri and Esraa Al-Qattan and Haytham Ramzy and Hany A Elrahman and Aisha Al-Qattan and Latifah Al-Kandari and Iman Al-Shammeri},
  title = {Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {5},
  pages = {221-225},
  doi = {10.11648/j.ajim.20200805.15},
  url = {https://doi.org/10.11648/j.ajim.20200805.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200805.15},
  abstract = {The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the infectious disease COVID-19, was declared a global pandemic in March 2020. The SARS-CoV-2 infection has polymorphic clinical presentations. The real time PCR is the reference diagnostic test; however, it can only detect the presence of virus for a specific window of time and its sensitivity has been reported as low as 60–70%. Case: We report a clinical case for a 28-year-old male patient. His clinical history included known NHL (large B-cell lymphoma) that treated with chemotherapy and autologous bone marrow transplant in 2017. He initially presented with fewer, URTI (upper respiratory infection) and weight loss to have a PET/CT scan for restaging. The follow up PET/CT scan, suggested no worrisome FDG metabolic activity elsewhere to suggest disease recurrence, though, hypermetabolic mediastinal lymph nodes, which were kept with active infectious process and bilateral FDG-avid ground glass attenuation in between the consolidation patches were noted. The follow up RT-PCR post PET/CT scan was proved to be positive. A developed pixelated quantitative map of CT part of the lung using MATLAB showed clearly severity of the lung disease that strongly suggested COVID-19 lung in association with the positive RT-PCR. FDG PET/CT has the potential to add value to the challenges of diagnosing complications caused by viruses such as COVID-19.},
 year = {2020}
}

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TY  - JOUR
T1  - Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report
AU  - Michael Masoomi
AU  - Alshaima Al-Shammeri
AU  - Esraa Al-Qattan
AU  - Haytham Ramzy
AU  - Hany A Elrahman
AU  - Aisha Al-Qattan
AU  - Latifah Al-Kandari
AU  - Iman Al-Shammeri
Y1  - 2020/08/25
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200805.15
DO  - 10.11648/j.ajim.20200805.15
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 221
EP  - 225
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200805.15
AB  - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the infectious disease COVID-19, was declared a global pandemic in March 2020. The SARS-CoV-2 infection has polymorphic clinical presentations. The real time PCR is the reference diagnostic test; however, it can only detect the presence of virus for a specific window of time and its sensitivity has been reported as low as 60–70%. Case: We report a clinical case for a 28-year-old male patient. His clinical history included known NHL (large B-cell lymphoma) that treated with chemotherapy and autologous bone marrow transplant in 2017. He initially presented with fewer, URTI (upper respiratory infection) and weight loss to have a PET/CT scan for restaging. The follow up PET/CT scan, suggested no worrisome FDG metabolic activity elsewhere to suggest disease recurrence, though, hypermetabolic mediastinal lymph nodes, which were kept with active infectious process and bilateral FDG-avid ground glass attenuation in between the consolidation patches were noted. The follow up RT-PCR post PET/CT scan was proved to be positive. A developed pixelated quantitative map of CT part of the lung using MATLAB showed clearly severity of the lung disease that strongly suggested COVID-19 lung in association with the positive RT-PCR. FDG PET/CT has the potential to add value to the challenges of diagnosing complications caused by viruses such as COVID-19.
VL  - 8
IS  - 5
ER  -

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Author Information

Michael Masoomi

Nuclear Medicine and Molecular Imaging Section, Department of Medical Imaging, ADAN Hospital, Ministry of Health, Hadiya, Kuwait
Alshaima Al-Shammeri

Nuclear Medicine and Molecular Imaging Section, Department of Medical Imaging, ADAN Hospital, Ministry of Health, Hadiya, Kuwait
Esraa Al-Qattan

Nuclear Medicine and Molecular Imaging Section, Department of Medical Imaging, ADAN Hospital, Ministry of Health, Hadiya, Kuwait
Haytham Ramzy

Radiology Section, Department of Medical Imaging, ADAN Hospital, Ministry of Health, Hadiya, Kuwait
Hany A Elrahman

Nuclear Medicine and Molecular Imaging Section, Department of Medical Imaging, ADAN Hospital, Ministry of Health, Hadiya, Kuwait
Aisha Al-Qattan

Nuclear Medicine and Molecular Imaging Section, Department of Medical Imaging, ADAN Hospital, Ministry of Health, Hadiya, Kuwait
Latifah Al-Kandari

Radiology Section, Department of Medical Imaging, ADAN Hospital, Ministry of Health, Hadiya, Kuwait
Iman Al-Shammeri

Nuclear Medicine and Molecular Imaging Section, Department of Medical Imaging, ADAN Hospital, Ministry of Health, Hadiya, Kuwait

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APA Style

Michael Masoomi, Alshaima Al-Shammeri, Esraa Al-Qattan, Haytham Ramzy, Hany A Elrahman, et al. (2020). Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report. American Journal of Internal Medicine, 8(5), 221-225. https://doi.org/10.11648/j.ajim.20200805.15

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ACS Style

Michael Masoomi; Alshaima Al-Shammeri; Esraa Al-Qattan; Haytham Ramzy; Hany A Elrahman, et al. Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report. Am. J. Intern. Med. 2020, 8(5), 221-225. doi: 10.11648/j.ajim.20200805.15

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AMA Style

Michael Masoomi, Alshaima Al-Shammeri, Esraa Al-Qattan, Haytham Ramzy, Hany A Elrahman, et al. Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report. Am J Intern Med. 2020;8(5):221-225. doi: 10.11648/j.ajim.20200805.15

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@article{10.11648/j.ajim.20200805.15,
  author = {Michael Masoomi and Alshaima Al-Shammeri and Esraa Al-Qattan and Haytham Ramzy and Hany A Elrahman and Aisha Al-Qattan and Latifah Al-Kandari and Iman Al-Shammeri},
  title = {Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {5},
  pages = {221-225},
  doi = {10.11648/j.ajim.20200805.15},
  url = {https://doi.org/10.11648/j.ajim.20200805.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200805.15},
  abstract = {The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the infectious disease COVID-19, was declared a global pandemic in March 2020. The SARS-CoV-2 infection has polymorphic clinical presentations. The real time PCR is the reference diagnostic test; however, it can only detect the presence of virus for a specific window of time and its sensitivity has been reported as low as 60–70%. Case: We report a clinical case for a 28-year-old male patient. His clinical history included known NHL (large B-cell lymphoma) that treated with chemotherapy and autologous bone marrow transplant in 2017. He initially presented with fewer, URTI (upper respiratory infection) and weight loss to have a PET/CT scan for restaging. The follow up PET/CT scan, suggested no worrisome FDG metabolic activity elsewhere to suggest disease recurrence, though, hypermetabolic mediastinal lymph nodes, which were kept with active infectious process and bilateral FDG-avid ground glass attenuation in between the consolidation patches were noted. The follow up RT-PCR post PET/CT scan was proved to be positive. A developed pixelated quantitative map of CT part of the lung using MATLAB showed clearly severity of the lung disease that strongly suggested COVID-19 lung in association with the positive RT-PCR. FDG PET/CT has the potential to add value to the challenges of diagnosing complications caused by viruses such as COVID-19.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Value of PET/CT and MATLAB in Detection of COVID-19 in an Oncology Patient - Case Report
AU  - Michael Masoomi
AU  - Alshaima Al-Shammeri
AU  - Esraa Al-Qattan
AU  - Haytham Ramzy
AU  - Hany A Elrahman
AU  - Aisha Al-Qattan
AU  - Latifah Al-Kandari
AU  - Iman Al-Shammeri
Y1  - 2020/08/25
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200805.15
DO  - 10.11648/j.ajim.20200805.15
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 221
EP  - 225
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200805.15
AB  - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the infectious disease COVID-19, was declared a global pandemic in March 2020. The SARS-CoV-2 infection has polymorphic clinical presentations. The real time PCR is the reference diagnostic test; however, it can only detect the presence of virus for a specific window of time and its sensitivity has been reported as low as 60–70%. Case: We report a clinical case for a 28-year-old male patient. His clinical history included known NHL (large B-cell lymphoma) that treated with chemotherapy and autologous bone marrow transplant in 2017. He initially presented with fewer, URTI (upper respiratory infection) and weight loss to have a PET/CT scan for restaging. The follow up PET/CT scan, suggested no worrisome FDG metabolic activity elsewhere to suggest disease recurrence, though, hypermetabolic mediastinal lymph nodes, which were kept with active infectious process and bilateral FDG-avid ground glass attenuation in between the consolidation patches were noted. The follow up RT-PCR post PET/CT scan was proved to be positive. A developed pixelated quantitative map of CT part of the lung using MATLAB showed clearly severity of the lung disease that strongly suggested COVID-19 lung in association with the positive RT-PCR. FDG PET/CT has the potential to add value to the challenges of diagnosing complications caused by viruses such as COVID-19.
VL  - 8
IS  - 5
ER  -

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